John McMurray, professor of cardiology at Western Infirmary, said that a third of patients with heart failure have evidence of diabetes, for whom effective treatment is “very difficult”.
The latest report from Euroaspire, Europe’s largest survey of cardiovascular risk factors in coronary patients, found the prevalence of obesity had increased from 25 percent in 1997 to 38 percent in just 10 years. These were people who had already had at least one heart attack.
Cardiologists emphasised that obesity is not just associated with an increased risk of heart attack, but also with an increased risk of heart failure.
“Obesity is at least as great a risk factor for heart failure as it is for heart attack or stroke,” said McMurray. “Obesity more than doubles the risk.”
The pathways by which obesity plays such a role in heart failure are not yet fully understood, but have been shown to have an indirect effect via hypertension, or heart attack, or diabetes and a direct effect on the heart muscle itself.
“We know that the underlying changes in the structure and function of the heart may be different in obese and non-obese patients with heart failure,” said McMurray.
Heart failure patients with diabetes also have worse symptoms, a higher risk of hospitalisation and a greater risk of death than those without diabetes - suggesting that the underlying pathophysiology of heart failure may be different in diabetics and non-diabetics.
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Related?Updated labelling of Actos regarding heart disease December 21st, 2008 The recent label of diabetes drug Actos has gone through a big change and is updated. The current Product Monograph for Actos contains the following new or updated information:
- Actos should not be used in patients with any stage of heart failure (Contraindications section)
- Actos is not approved for use with metformin and a sulfonylurea. Diabetes drug found linked with heart failure and deathAugust 22nd, 2008 Thousands of diabetics taking Avandia and Avandamet are told to go the doctor fro check up. Thousands of Australians are advised to go to doctor after major changes were made to the drugs' guidelines for use.The changes, ordered by the Therapeutic Goods Administration (TGA), come after two major studies released last year showed the products doubled the risk of heart failure and death in some people. PPAR-gamma Agonists Diabetes Drug Increases Risk Of Heart FailureSeptember 13th, 2007 PPAR-gamma agonists drugs which are used to treat individuals with diabetes, are associated with a slightly increased risk of heart failure, a new study says. In the study, Ira Goldberg and colleagues at Columbia University, New York, generated mice expressing increased amounts of PPAR-gamma in the heart compared with normal mice to determine the effects of increased PPAR-gamma activity in the heart. Retinopathy in Diabetics Doubles Heart Failure RiskMay 8th, 2008 Diabetic Retinopathy can increase the chances of heart problems among the diabetes patients, found researchers. The disease, which affects roughly half of diabetics in the U.S., is caused by damage to the blood vessels in the back of the eye. A class of Diabetic medications have higher risk of heart failure and death December 1st, 2008 A new class of diabetic medication thiazolidinediones and two agents in this class, rosiglitazone maleate and pioglitazone hydrochloride, (were approved and marketed beginning in 1999.), though offered several clinical benefits, like-
Decreased insulin resistance. Better control of blood sugar. Diabetes type 3 poses serious public threatFebruary 10th, 2009 Researchers are in contradictory views regarding the hottest addition in the health sphere. It's Diabetes type 3 .Nobody seems to be quite sure how this newest member of the diabetes family can be described. Diabetes drug harmful for health December 4th, 2008 Researchers at Brigham and Women's Hospital and Harvard Medical School have concluded that diabetes drug like rosiglitazone may increase older patients' risk of death and heart failure. A black box warning was recently added to two drugs, rosiglitazone and pioglitazone hydrochloride. Beware of Diabetic drug Rosiglitazone and pioglitazone which increases cardiovascular riskAugust 29th, 2008 Latest news reveals that type 2 diabetic drug named Rosiglitazone and pioglitazone, increases the chance of heart failure. This is what is published online in Heart Wednesday by professor of internal medicine, and Curt D. Obesity and diabetes double heart failure risk
Get all the information and photos:: http://coringa.info/uncategorized/obesity-and-diabetes-double-heart-failure-risk
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