does bupropion have any affect on the metabolism of methadone?

I know some meds speed up or slow down metaboism of other drugs due to CYP 450 enzymes. I haven't found a website that explains what bupropion does to methadone in the body. any insight into this will be great, thanx.

: http://alcoholdrugstreatment.info/does-bupropion-have-any-affect-on-the-metabolism-of-methadone